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MYP_086730
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Basic Information
Paneth cell-specific alpha-defensin 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
34 amino acids
C167H272N62O46S6
Standard
Sequence
SCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR
Physicochemical Analysis
4076.72 Da
9.69
6.49
6.14
0.1908
-0.93
0.59
-0.43
69.85
37.35
0.0882
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1808.29
-22.17
76.0
60.0
136.0
281.0
6.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0328098 VERIFIED: NO
Provenance & Taxonomy
Mammalia [Animal]
40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0332385 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis PEG 205
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
RECORD: Rec_0342802 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli D31
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
RECORD: Rec_0377336 VERIFIED: YES
Provenance & Taxonomy
Paneth cells [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
horse pathogens such as R. equi ATCC 33701 P ,R. equi ATCC 33701 P+, R. equi 85 FP+ S. equi subsp. zooepidemicus ,S. equi subsp. equi, S. dysgalactiae subsp. equisimilis , S. choleraesuis . Membrane permeabilization is at least an essential part of the peptide's mode of action. 3D structure of the peptide has been determned by 2D NMR spectroscopy (Michalek M et al., 2015). Residues 3-6, 15-17
PaperA novel horse alpha-defensin: gene transcription, recombinant expression and characterization of the structure and function.
RECORD: Rec_0413201 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 6538
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
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