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MYP_086730
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Basic Information
Paneth cell-specific alpha-defensin 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
34 amino acids
C167H272N62O46S6
Standard
Sequence
SCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR
Physicochemical Analysis
4076.72 Da
9.69
6.49
6.14
0.1908
-0.93
0.59
-0.43
69.85
37.35
0.0882
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1808.29
-22.17
76.0
60.0
136.0
281.0
6.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0162016 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
RECORD: Rec_0165522 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterobacter cloacae ATCC 13047
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
RECORD: Rec_0169017 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0194884 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
S. pyogenes ATCC 12344
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
RECORD: Rec_0197235 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 11775
PMID17620056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17620056/
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