Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length478 amino acids

Chemical FormulaC2391H3692N622O679S16

DescriptionStandard

        MDFAYRLTFLFSIAAFVGTADAENPGLVVRVTQKGLDYALHEGVIALQQQLSHIQLGEISDTHSLGFFLGKARYKIFGMNLGNVQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVRYSFIHEDGTFNIKVGGLGMSVGLNLRNIENGKPTVSVADCSCHIANVEVHMSGTIGWLVELFHGAVESKIRKELEDKICPEIHKYINSDVSPFLRNQPVNRNINPISGLDYSLTGPPSVMGNWLDVFLKGEFYKNGENPHTAPPFAPPVMSLPPEQDHMVYFAVSDYVFNTAFLTYQRAGALVFDLRDDMIPREFGIHLNTNLLERVIPSVSKMYPNMPMMLKISAASTPALNINPGGLTLSPVGNIQAYAILPNSSPAPLFLLQAKTNAFAKVAVNSGNIVLSLEHGNVEVSLSHSDVGPFSVSEINSVMNLLVPVVLPHVNDFLRNGFPLTFIEHIQLGDIVIKTYEHYLLFGANVQYQ
    

Molecular Weight52527.69 Da

Isoelectric Point (pI)5.87

Net Charge (pH 7.0)-9.08

Net Charge (pH 7.4) -10.25

Charge Density (pH 7.0) -0.0190

GRAVY Index0.10

Hydrophobic Moment 0.71

Boman Index0.18

Instability Index43.86

Aliphatic Index 98.64

Aromaticity 0.0983

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169689 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria