‹ ›
MYP_086569
← PREVIOUS NEXT → BACK
Basic Information
Esculentin-1GN
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
49 amino acids
C225H379N63O61S2
Standard
Sequence
GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC
Physicochemical Analysis
5006.93 Da
9.87
6.74
6.49
0.1375
-0.08
0.71
0.08
12.39
85.51
0.0612
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2007.90
-18.69
73.0
70.0
182.0
351.0
4.0
48.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0141032 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID30427189 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30427189/
RECORD: Rec_0142652 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana guentheri [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
43-49
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antioxidant Anti-inflammatory Anticancer
Candida albicans
4.7 μM
MIC
PaperFunctional characterization of A Novel Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide in vitro and in vivo
RECORD: Rec_0152995 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana guentheri [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
43-49
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antioxidant Anti-inflammatory Anticancer
P. acnes
1.17 μM
MIC
PaperFunctional characterization of A Novel Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide in vitro and in vivo
RECORD: Rec_0311591 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0318342 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID30427189 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30427189/
FIRST PREV 1 2 3 NEXT LAST
Showing 5 records on this page · Page 2 of 3