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MYP_086569
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Basic Information
Esculentin-1GN
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
49 amino acids
C225H379N63O61S2
Standard
Sequence
GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC
Physicochemical Analysis
5006.93 Da
9.87
6.74
6.49
0.1375
-0.08
0.71
0.08
12.39
85.51
0.0612
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2007.90
-18.69
73.0
70.0
182.0
351.0
4.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0029835 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID30427189 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30427189/
RECORD: Rec_0044568 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana guentheri [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
43-49
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antioxidant Anti-inflammatory Anticancer
Pseudomonas aeruginosa
50 μM
MIC
PaperFunctional characterization of A Novel Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide in vitro and in vivo
RECORD: Rec_0066053 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana guentheri [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
43-49
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antioxidant Anti-inflammatory Anticancer
Staphylococcus aureus ATCC 25923 or ampicillin and benzylpencillin-resistant
1.9-40 μM
MIC
PaperFunctional characterization of A Novel Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide in vitro and in vivo
RECORD: Rec_0088204 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID30427189 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30427189/
RECORD: Rec_0136647 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hylarana guentheri [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
43-49
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antioxidant Anti-inflammatory Anticancer
S. subtilis ATCC 6633
3.1 μM
MIC
PaperFunctional characterization of A Novel Lipopolysaccharide-binding Antimicrobial and Anti-inflammatory Peptide in vitro and in vivo
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