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MYP_086515
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Basic Information
Esculentin-1PLb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
46 amino acids
C219H378N60O62S3
Standard
Sequence
GIFTKINKKKAKTGVFNIIKTIGKEAGMDVIRAGIDTISCKIKGEC
Physicochemical Analysis
4939.90 Da
9.76
5.74
5.49
0.1248
0.00
0.67
0.04
19.60
95.43
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2005.43
-18.74
72.0
71.0
179.0
344.0
2.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169595 VERIFIED: YES
Provenance & Taxonomy
Rana palustris [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
1 μM
MIC
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0265427 VERIFIED: YES
Provenance & Taxonomy
Pickerel frog [Animal]
Esculentin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0282756 VERIFIED: NO
Provenance & Taxonomy
Odorrana versabilis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperEsculentin-1Vb Evidence URLhttps://www.uniprot.org/uniprotkb/Q1JS87/entry
RECORD: Rec_0298364 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
15.0 μM
MIC
PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0314459 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Esculentin
298395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial
Escherichia coli
1 μM
MIC
PaperMultiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
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