Peptide Database

Peptide NameSLAY-screened peptide P4797

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC93H140N24O22

DescriptionStandard

        FYYRLSAHIHPTSILK
    

Molecular Weight1946.25 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.93

Net Charge (pH 7.4) 1.62

Charge Density (pH 7.0) 0.1207

GRAVY Index-0.01

Hydrophobic Moment 0.35

Boman Index0.13

Instability Index61.69

Aliphatic Index 103.75

Aromaticity 0.1875

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 737.46

LogP -3.79

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 59.0

Heavy Atoms 139.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406507 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/