Peptide Database

Peptide NamePea-FMRFa-22

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC91H141N27O40

DescriptionStandard

        SGPSYDEKEQENEDGNSVRL
    

Molecular Weight2253.25 Da

Isoelectric Point (pI)4.08

Net Charge (pH 7.0)-4.53

Net Charge (pH 7.4) -4.75

Charge Density (pH 7.0) -0.2264

GRAVY Index-1.90

Hydrophobic Moment 0.27

Boman Index-0.41

Instability Index55.62

Aliphatic Index 34.00

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1129.34

LogP -16.18

H-bond Donors 37.0

H-bond Acceptors 36.0

Rotatable Bonds 77.0

Heavy Atoms 158.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007370 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyFMRFamide related peptide

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0114585 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyPea-FMRFa

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0351189 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/