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MYP_086445
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Basic Information
Aurein-1.2 [E11A]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C69H111N15O17
Standard
Sequence
GLFDIIKKIAASF
Physicochemical Analysis
1422.71 Da
8.59
0.76
0.55
0.0584
1.08
0.60
0.40
5.66
135.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
522.09
-1.72
18.0
18.0
48.0
101.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256012 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis PCM 2673
32 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0257081 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis
32 μg/mL
MIC
Fetal bovine serum: 37℃，in fetal bovine serum, 17% remaining after 6 h
PaperMigoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W. Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2. Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054. PMID:30569430 https://pubmed.ncbi.nlm.nih.gov/30569430/ PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0273209 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
32 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0369872 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 9027
64 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0373689 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
16 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
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