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MYP_086422
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Basic Information
Aurein-5.2 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C110H194N28O32S
Standard
Sequence
GLMSSIGKALGGLIVDVLKPKTPAS
Physicochemical Analysis
2452.95 Da
9.70
1.76
1.55
0.0703
0.60
0.47
0.29
28.30
124.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
940.42
-8.83
32.0
35.0
82.0
171.0
2.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0151692 VERIFIED: YES
Provenance & Taxonomy
Ranoidea raniformis [Animal]
116057
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
S. uberis
50 μg/mL
MIC
PaperThe antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
RECORD: Rec_0154546 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
-
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0163531 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Aurein
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis
100 μg/mL
MIC
PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
RECORD: Rec_0167585 VERIFIED: NO
Provenance & Taxonomy
Litoria aurea [Animal]; Litoria raniformis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0169581 VERIFIED: YES
Provenance & Taxonomy
Green and [Animal]
Aurein
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22800690 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22800690/
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