Peptide Database

Peptide NameSLAY-screened peptide P4647

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC63H107N25O17

DescriptionStandard

        IHRRISTVHRDP
    

Molecular Weight1486.68 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.1613

GRAVY Index-1.11

Hydrophobic Moment 0.72

Boman Index-0.46

Instability Index67.18

Aliphatic Index 89.17

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 695.45

LogP -7.45

H-bond Donors 26.0

H-bond Acceptors 21.0

Rotatable Bonds 47.0

Heavy Atoms 105.0

Ring Count 3.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420519 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/