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MYP_086356
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Basic Information
HRA3
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C158H277N47O53
Standard
Sequence
LESEVTAIKNALKKTNEAVSTLGNGVRVLATAVRE
Physicochemical Analysis
3683.17 Da
8.50
0.77
0.56
0.0221
-0.02
0.72
-0.01
2.43
111.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1654.43
-19.74
58.0
54.0
128.0
258.0
0.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110033 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
LLC-MK2 cells at the highest concentrations tested (9 μM)
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0159872 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0185910 VERIFIED: YES
Provenance & Taxonomy
Human metapneumovirus [Virus]
Virus-derived peptide
162145;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
Human metapneumovirus (Virus entry); LLC-MK2
3.24 μM
RT-PCR
PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0188493 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MPV Fusion inhibition
Human Metapneumovirus(hMPV) | LLC-MK2 cells
3.24 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 Jan;52(1):279-87. | DOI:10.1128/AAC.00793-07 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0205162 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 88.6%, E 0.0%, T 2.9%, C 8.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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