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MYP_086332
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Basic Information
gamma-2 purothionin; wheat (Triticum aestivum)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
47 amino acids
C211H343N73O62S8
Standard
Sequence
KVCRQRSAGFKGPCVSDKNCAQVCLQEGWGGGNCDGPFRRCKCIRQC
Physicochemical Analysis
5150.95 Da
9.12
5.68
5.35
0.1209
-0.60
0.45
-0.22
50.45
39.36
0.0638
5500.00
6000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2224.61
-29.68
85.0
76.0
173.0
354.0
6.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0047586 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Thionin
4565;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperGamma-purothionins: amino acid sequence of two polypeptides of a new family of thionins from wheat endosperm.FEBS Lett. 270:191-194 Evidence URLhttps://www.uniprot.org/uniprotkb/P20159/entry
RECORD: Rec_0095620 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Thionin
4565
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Cytotoxic Antimicrobial Antibacterial Protein Synthesis Inhibitor Anti-Gram-negative
Salmonella typhimurium SL1344
PaperPubMed PMID 2226781 | PubMed PMID 27208129 PMID2226781;27208129;22267812;7208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0192142 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Thionin
4565
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Cytotoxic Antimicrobial Antibacterial Protein Synthesis Inhibitor Anti-Gram-positive
Staphylococcus aureus Newman
PaperPubMed PMID 2226781 | PubMed PMID 27208129 PMID2226781;27208129;22267812;7208129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0243349 VERIFIED: YES
Provenance & Taxonomy
Triticum aestivum [Plant]
Defensin
4565
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antifungal
PaperPubMed PMID: 2226781 PMID2226781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2226781/
RECORD: Rec_0271017 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 21.3%, E 36.2%, T 23.4%, C 19.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
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