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MYP_086325
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Basic Information
vitri C
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C124H193N35O39S6
Standard
Sequence
GLPICGETCVGGTCNTPGCFCTWPVCTRN
Physicochemical Analysis
2990.46 Da
5.96
-0.30
-0.59
-0.0102
0.29
0.26
0.21
34.77
46.90
0.0690
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1154.07
-15.62
45.0
45.0
86.0
204.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005336 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
BEL-7402
10 μg/mL
IC50
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0085008 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human breast adenocarcinoma MDA-MB-231
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0092147 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial Hemolytic
Human erythrocytes
11.53 μM
EC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0132971 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human prostate cancer DU145
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0146759 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human glioblastoma U251-MG
46.96 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining PMID20580652;26399490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
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