Peptide Database

Peptide NameT-253

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC169H277N47O54

DescriptionStandard

        DAVYLHRIDLGPPISLERLDVGTNLQNAIAKLEDA
    

Molecular Weight3831.29 Da

Isoelectric Point (pI)4.52

Net Charge (pH 7.0)-3.14

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.0898

GRAVY Index-0.07

Hydrophobic Moment 0.51

Boman Index0.05

Instability Index16.31

Aliphatic Index 128.29

Aromaticity 0.0286

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1627.40

LogP -14.45

H-bond Donors 54.0

H-bond Acceptors 52.0

Rotatable Bonds 126.0

Heavy Atoms 270.0

Ring Count 4.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0336584 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-MeV Entry inhibition

TargetMeasles virus (MV) | HEp-2 cells

Activity26.1 μM

MethodEC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

RECORD: Rec_0391516 VERIFIED: YES