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MYP_086324
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Basic Information
T-253
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C169H277N47O54
Standard
Sequence
DAVYLHRIDLGPPISLERLDVGTNLQNAIAKLEDA
Physicochemical Analysis
3831.29 Da
4.52
-3.14
-3.41
-0.0898
-0.07
0.51
0.05
16.31
128.29
0.0286
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1627.40
-14.45
54.0
52.0
126.0
270.0
4.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033128 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
measles virus(MV):protection of HEp2 cell from viral cytopathic effect(CPE)
100 μg/mL
EC50
PaperPubMed PMID: 8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0099404 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 45.7%, E 0.0%, T 14.3%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0100102 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0125135 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
No significant cytotoxic against HEp2 cells
100 μM
CC50
PaperPubMed PMID: 8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0236951 VERIFIED: YES
Provenance & Taxonomy
Measles morbillivirus [Virus]
Virus-derived peptide
11234;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor Cytoprotective
Measles virus (Fusion); HEp2
100 μM
EC50
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
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