Peptide Database

Peptide NamePea-FMRFa-2

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC58H101N25O15S

DescriptionStandard

        RRCSNRNFVRL
    

Molecular Weight1420.65 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.75

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.3409

GRAVY Index-1.14

Hydrophobic Moment 0.49

Boman Index-0.75

Instability Index58.72

Aliphatic Index 61.82

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 708.33

LogP -9.08

H-bond Donors 28.0

H-bond Acceptors 20.0

Rotatable Bonds 48.0

Heavy Atoms 99.0

Ring Count 1.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006089 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyPea-FMRFa

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator ACE inhibitory

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0136658 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyFMRFamide related peptide

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0376533 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/