Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2593H4033N647O742S19

DescriptionStandard

        MCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP
    

Molecular Weight56751.88 Da

Isoelectric Point (pI)5.85

Net Charge (pH 7.0)-6.62

Net Charge (pH 7.4) -7.54

Charge Density (pH 7.0) -0.0130

GRAVY Index0.10

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index38.47

Aliphatic Index 100.39

Aromaticity 0.1063

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042146 VERIFIED: NO

Provenance & Taxonomy

OrganismBos indicus x Bos taurus [Animal]

FamilyBPI

Tax ID30522

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence