Peptide Database

Peptide Namealpha-Atrial natriuretic peptide-32

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC145H236N52O44S3

DescriptionStandard

        TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY
    

Molecular Weight3507.94 Da

Isoelectric Point (pI)11.33

Net Charge (pH 7.0)4.38

Net Charge (pH 7.4) 4.16

Charge Density (pH 7.0) 0.1368

GRAVY Index-0.59

Hydrophobic Moment 0.62

Boman Index-0.24

Instability Index91.16

Aliphatic Index 42.81

Aromaticity 0.0938

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1593.12

LogP -23.15

H-bond Donors 62.0

H-bond Acceptors 52.0

Rotatable Bonds 116.0

Heavy Atoms 244.0

Ring Count 4.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0083990 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide13-29

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0220340 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyUrodilatin

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Disulfide11-27

Other Mods10:Phosphoserine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour