Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length461 amino acids

Chemical FormulaC2280H3660N598O651S17

DescriptionStandard

        RTLLWLFKSTLSSNGTNPGVKVKLTEKGLEYGRQLGMVSIQQKLKSIKVPDFSGSQTVSPIGNVKYSLSNMCIVSVGLPQSAVNLVQGTGMRLSVSNAFISLRGNWKVKYLHIIKDSGSFDLKVKGLTIGTSIAIKSDETGRPAVSNVNCGATVSSASVKFHGGASWLYNLFRKFIDKALRSAMQKQMCPLVTNAISDLNPQLKTLNVLAKVDQYAEIEYSMVSSPIVSNSSIDFSLKGEFYNIGKHQEPPFSPSAFTLPSQINNMLYIGMSAFTANSAAFVYNKAGALHLFVTDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVQTVKPPVTTFEPNNLTVQASSTVTAYAIQPNTTLSPLFVLNLVDEHHSLILPHLHRMTLTLGTSYVGEFQVRSLDSILQLVLKVVVIPRLNVQLAKGYPLPALGKMKLVNTQLEVLKDYMLIGTDVQFTG
    

Molecular Weight50410.17 Da

Isoelectric Point (pI)9.73

Net Charge (pH 7.0)19.43

Net Charge (pH 7.4) 18.68

Charge Density (pH 7.0) 0.0421

GRAVY Index0.11

Hydrophobic Moment 0.85

Boman Index0.13

Instability Index32.40

Aliphatic Index 100.80

Aromaticity 0.0803

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 35995.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0186978 VERIFIED: NO

Provenance & Taxonomy

OrganismLates calcarifer [Bacterium]

FamilyBPI

Tax ID8187

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence