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MYP_086113
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Basic Information
Maximin 5
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
27 amino acids
C133H218N32O36
Standard
Sequence
SIGAKILGGVKTFFKGALKELASTYLQ
Physicochemical Analysis
2841.35 Da
9.82
2.46
2.24
0.0910
0.40
0.60
0.24
15.62
108.52
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1105.54
-8.65
39.0
39.0
98.0
201.0
3.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0029879 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-positive Anti-Gram-negative
Bacillus dysenteriae
12 μg/mL
MIC
PMID11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835991/
RECORD: Rec_0066793 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Spermicidal
B. dysenterium
12 μM
MIC
PaperAntimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
RECORD: Rec_0069678 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-positive Anti-Gram-negative
Penicillium uticale IFFI2001
12 μg/mL
MIC
PMID11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835991/
RECORD: Rec_0071113 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral Anticancer
Cancer cell lines: C8166
34.4 μg/mL
IC50
PaperVariety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification. Eur J Immunol. 2005 Apr;35(4):1220-1229. doi: 10.1002/eji.200425615. PMID: 15770703. | Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 2002 Mar;23(3):427-435. doi: 10.1016/S0196-9781(01)00641-6. PMID: 11835991. PMID15770703;11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15770703/
RECORD: Rec_0083296 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1
34.4 μg/mL
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperAntimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. | Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y. | Peptides. 2002 Mar;23(3):427-435. | PMID:11835991 PMID11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835991/
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