Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length449 amino acids

Chemical FormulaC2289H3577N601O641S13

DescriptionStandard

        AHQHGIAVLEKELTKVKVPDISGDFRIRHVGKVHYELSRLDLRSFHLPYSRISLLPSLGLQVSISNAFASVDGNWRVKLYFIRDHGSFDLRVENVYIKINLKLGKDSSGKPTISTSDCSTHISKVWVHFSGKLGWLYNLFYRAVEQRFRKILESKVASLHLFLQVCDMVANSVHTELQPYAQTLPVTSKIDDMVGIDYALVAPPAATAQSLDVDLKGEFYSLAHRSAVPFSPLPLALPPDHDHMVYFGVSSYFLNTASFAYHTAGALVFEITDSMIPKDVEFHLTTSTFSAFIPELEKMYPNTPMKLRLFSPSPPFLSITPEGLSLRPVVDIQAYAILSSDHLAPLFLLSLVSNVSAVINVSSGHIVGNLTMGRMKLSLKHSDVGTFQVRTLQSMMNIYTSSILLPNLNERLGQGFPLPLPDRIKLHNTIVRFQQDSLMLGADVHYEPR
    

Molecular Weight50188.37 Da

Isoelectric Point (pI)8.37

Net Charge (pH 7.0)3.55

Net Charge (pH 7.4) 2.23

Charge Density (pH 7.0) 0.0079

GRAVY Index0.06

Hydrophobic Moment 0.74

Boman Index0.12

Instability Index39.67

Aliphatic Index 101.78

Aromaticity 0.0958

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0249521 VERIFIED: NO

Provenance & Taxonomy

OrganismCalypte anna [Animal]

FamilyBPI/LBP

Tax ID9244

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria