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MYP_085992
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Basic Information
LK [L8K]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
16 amino acids
C89H171N23O17
Standard
Sequence
LKKLLKLKKKLLKLAG
Physicochemical Analysis
1835.45 Da
10.78
6.75
6.54
0.4221
0.04
0.63
-0.12
-33.08
176.88
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
681.96
-0.45
24.0
24.0
73.0
129.0
0.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023726 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (10% Hemolysis at 160 μM
160 μM
Hemolysis
PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0079909 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0117047 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0229003 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
5 μM
MIC
PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
RECORD: Rec_0267347 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-negative bacteria: Escherichia coli (ATCC 25922)
5 μM
MIC
PaperDisruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides PMID23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23894079/
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