Peptide Database

Peptide NamePep19-2.5

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC135H187N37O22S

DescriptionStandard

        GCKKYRRFRWKFKGKFWFWG
    

Molecular Weight2712.23 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)7.74

Net Charge (pH 7.4) 7.52

Charge Density (pH 7.0) 0.3872

GRAVY Index-1.23

Hydrophobic Moment 0.50

Boman Index-0.30

Instability Index37.13

Aliphatic Index 0.00

Aromaticity 0.4000

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 999.62

LogP -2.04

H-bond Donors 40.0

H-bond Acceptors 31.0

Rotatable Bonds 88.0

Heavy Atoms 195.0

Ring Count 11.0

Amide Bonds 19.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0416185 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HBV Entry inhibition

TargetHepatitis B virus (HBV) | 293T cells

Activity1 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperA new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses. | Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U. | J Infect Dis. 2012 Jun;205(11):1654-64. | DOI:10.1093/infdis/jis273 | PMID:22457281 PMID22457281 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22457281/

FIRST PREV 1 2 3 4

Showing 1 records on this page Ã‚Â· Page 4 of 4