Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2291H3644N592O641S19

DescriptionStandard

        MTLCWWFLLVAFIPMTSGTNPGVKVKLTEKGLEYGRQLGMVSIQQKLKSIKVPDFSGSQTVSPIGNVKYSFMCIVSVGLPQSAVNLVQGTGMRLSVSNAFISLRGNWKVKYLHIIKDSGSFDLKVKGLTIGTSIAIKSDETGRPAVSNVNCGATVSSASVKFHGGASWLYNLFRKFIDKALRSAMQKQVRGNWLYAHFLAKVDQYAEIEYSMVSSPIVSNSSIDFSLKGEFYNIGKHQEPPFSPSAFTLPSQINNMLYIGMSAFTANSAAFVYNKAGALHLFVTDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVQTVKPPVTTFEPNNLTVQASSTVTAYAIQPNTTLSPLFVLNLETSVSAQVFVRGMRLAGAVTLNKMTLTLGTSYVGEFQVRSLDSILQLVLKVVVIPRLNVQLAKGYPLPALGKMKLVNTQLEVLKDYMLIGTDVQFTG
    

Molecular Weight50346.26 Da

Isoelectric Point (pI)9.81

Net Charge (pH 7.0)20.91

Net Charge (pH 7.4) 20.30

Charge Density (pH 7.0) 0.0454

GRAVY Index0.19

Hydrophobic Moment 0.85

Boman Index0.16

Instability Index31.59

Aliphatic Index 97.85

Aromaticity 0.0957

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0300773 VERIFIED: NO

Provenance & Taxonomy

OrganismLates calcarifer [Bacterium]

FamilyBPI

Tax ID8187

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence