Peptide Database

Peptide NameUnnamed

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-1 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Lipase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC42H67N15O16S

DescriptionStandard

        GQLGEHGGAGMG
    

Molecular Weight1070.14 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0958

GRAVY Index-0.42

Hydrophobic Moment 0.27

Boman Index0.27

Instability Index-8.83

Aliphatic Index 40.83

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 492.49

LogP -7.57

H-bond Donors 16.0

H-bond Acceptors 17.0

Rotatable Bonds 36.0

Heavy Atoms 74.0

Ring Count 1.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390502 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory COX-1 Inhibitory

TargetCyclooxygenase-1 (COX-1)

Activity7.12 μg/mL

MethodIC50

PaperZ?otek U., Jakubczyk A., Rybczy¨½ska-Tkaczyk K., ?wiek P., Baraniak B., Lewicki S.. Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020. PMID32471271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32471271/

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