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MYP_085919
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Basic Information
Compound 8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RTRCXFLRXC
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0272373 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C9
Amidation
X=diaminobutyrate; f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Human dermal fibroblasts
461 μg/mL
IC50
PaperPubMed PMID: 26024044 PMID26024044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26024044/
RECORD: Rec_0341171 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
C9
Amidation
X=diaminobutyrate; f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer
PC-12
595 μg/mL
IC50
PaperPubMed PMID: 26024044 PMID26024044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26024044/
RECORD: Rec_0363181 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 5,9
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 8739
4 μg/mL
MIC
PMID26024044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26024044/
RECORD: Rec_0375217 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 5,9
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 6538
8 μg/mL
MIC
PMID26024044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26024044/
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