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MYP_085907
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
22 amino acids
C99H153N25O30S4
Standard
Sequence
IASKFICTPGCAKTGSFNSYCC
Physicochemical Analysis
2301.68 Da
8.52
1.72
1.45
0.0781
0.43
0.32
0.20
20.50
44.55
0.1364
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
882.14
-11.50
35.0
36.0
71.0
158.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0146546 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
752-5). MOA: It sequesters lipid II and inhibits cell wall synthesis (for ref, see mutacin 1140). It seems that activity of the lantibiotic epidermin is regulated at the level of precursor peptide processing (Kies S,et al. 2003). Updated 9/2012; 7/2021GW
Bio-Activity Profile
Antimicrobial
S. faecalis ATCC 29212
64 μg/mL
MIC
PaperEpidermin: sequencing of a heterodetic tetracyclic 21-peptide amide antibiotic.
RECORD: Rec_0168044 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium],DSM 3095 [Bacterium]
Bacteriocin
1282
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 2835685 | PubMed PMID: 3769923 PMID2835685;3769923 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2835685/
RECORD: Rec_0187907 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0223694 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
752-5). MOA: It sequesters lipid II and inhibits cell wall synthesis (for ref, see mutacin 1140). It seems that activity of the lantibiotic epidermin is regulated at the level of precursor peptide processing (Kies S,et al. 2003). Updated 9/2012; 7/2021GW
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis ATCC 12228
4 μg/mL
MIC
PaperEpidermin: sequencing of a heterodetic tetracyclic 21-peptide amide antibiotic.
RECORD: Rec_0225874 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus epidermidis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
752-5). MOA: It sequesters lipid II and inhibits cell wall synthesis (for ref, see mutacin 1140). It seems that activity of the lantibiotic epidermin is regulated at the level of precursor peptide processing (Kies S,et al. 2003). Updated 9/2012; 7/2021GW
Bio-Activity Profile
Antimicrobial
P. anaerobicus
0.25 μg/mL
MIC
PaperEpidermin: sequencing of a heterodetic tetracyclic 21-peptide amide antibiotic.
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