Peptide Database

Peptide NamePonericin-W1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Insecticidal/Pest control ▸ Insecticidal activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC130H221N33O29

DescriptionStandard

        WLGSALKIGAKLLPSVVGLFKKKKQ
    

Molecular Weight2710.35 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.2302

GRAVY Index0.24

Hydrophobic Moment 0.53

Boman Index0.14

Instability Index16.41

Aliphatic Index 124.80

Aromaticity 0.0800

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1008.39

LogP -4.95

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 95.0

Heavy Atoms 192.0

Ring Count 4.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0398945 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal

TargetStreptococcus pyogenes CIP 561(Inhibition zone = 10mm)

RECORD: Rec_0403280 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

FamilyPonericin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetSalmonella enterica CIP 813

RECORD: Rec_0415886 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal Hemolytic

Targethorse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 μl of the peptide solution and placed overnight at 4℃ to allow the diffusion of the hemolytic agent)

RECORD: Rec_0420707 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Insecticidal Antifungal

TargetPseudomonas aeruginosa CIP A22(Inhibition zone = 16mm)

RECORD: Rec_0425728 VERIFIED: YES

Provenance & Taxonomy

OrganismPachycondyla goeldii [Animal]

FamilyPonericin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetKlebsiella pneumoniae CIP 8291

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