Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC278H435N73O93S6

DescriptionStandard

        MKQFNLEALRAIEDISDDELMVITGAVSVIDAQASGGVFCTVSHECHYNSVSPSSWLTCC
    

Molecular Weight6480.25 Da

Isoelectric Point (pI)4.28

Net Charge (pH 7.0)-6.35

Net Charge (pH 7.4) -6.74

Charge Density (pH 7.0) -0.1059

GRAVY Index0.28

Hydrophobic Moment 0.72

Boman Index0.18

Instability Index66.80

Aliphatic Index 89.33

Aromaticity 0.0667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2646.02

LogP -29.77

H-bond Donors 95.0

H-bond Acceptors 95.0

Rotatable Bonds 211.0

Heavy Atoms 450.0

Ring Count 8.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016931 VERIFIED: NO

Provenance & Taxonomy

OrganismPaenibacillus xylanexedens [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

RECORD: Rec_0100543 VERIFIED: NO

Provenance & Taxonomy

OrganismPaenibacillus amylolyticus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence

RECORD: Rec_0125131 VERIFIED: YES

Provenance & Taxonomy

OrganismPaenibacillus sp. OVF10 [Bacterium]

FamilyLantibiotic

Tax ID2928702

Structure & Mods

Configgene-encoded linear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-positive bacteria

RECORD: Rec_0336722 VERIFIED: NO

Provenance & Taxonomy

OrganismPaenibacillus sp. CF095 [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria