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MYP_085839
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Basic Information
Cycloviolacin-Y5 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C132H209N33O42S6
Standard
Sequence
GIPCAESCVWIPCTVTALVGCSCSDKVCYN
Physicochemical Analysis
3122.66 Da
4.37
-1.30
-1.59
-0.0432
0.79
0.28
0.29
25.08
84.33
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1170.52
-13.13
46.0
47.0
93.0
213.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0241559 VERIFIED: YES
Provenance & Taxonomy
Chinese herb [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Toxicity
1.76 μM
TC50
PaperAnti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.
RECORD: Rec_0249069 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-21, 8-23, 13-28
Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28.
Bio-Activity Profile
Antiviral Entry inhibition
Effects
2.28 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPMID:18618891 PMID18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18618891/
RECORD: Rec_0267116 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0269033 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-21, 8-23, 13-28
Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28.
Bio-Activity Profile
Antiviral Entry inhibition
Effects
2.4 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPMID:18618891 PMID18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18618891/
RECORD: Rec_0273189 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-21, 8-23, 13-28
Disulfide bonds between Cys4 and Cys21; Cys8 and Cys23; Cys13 and Cys28.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.04 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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