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MYP_085839
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Basic Information
Cycloviolacin-Y5 (Plants)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C132H209N33O42S6
Standard
Sequence
GIPCAESCVWIPCTVTALVGCSCSDKVCYN
Physicochemical Analysis
3122.66 Da
4.37
-1.30
-1.59
-0.0432
0.79
0.28
0.29
25.08
84.33
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1170.52
-13.13
46.0
47.0
93.0
213.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110135 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Hemolytic Antiviral Anti-HIV
Haemonchus contortus
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081259 PMID18081259;18618891;18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081259/
RECORD: Rec_0118795 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antiviral
Effects: H
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0161659 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Hemolytic Antiviral Anti-HIV
HIV
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081259 PMID18081259;18618891;18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081259/
RECORD: Rec_0168298 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Hemolytic Antiviral Anti-HIV
Trichostrongylus colubriformis
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081259 PMID18081259;18618891;18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081259/
RECORD: Rec_0234084 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Toxic Antimicrobial Hemolytic Cytotoxic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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