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MYP_085774
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Basic Information
LP-86
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
29 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LEANIEELLKKAEEQQKKNEEELKKLEKX
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0353333 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16 = palmitic acid at 29; C16 = palmitic acid
Bio-Activity Profile
Antiviral
SHIV SF162P3
0.00009 μM
IC50
PMID29899103 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29899103/
RECORD: Rec_0359078 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16 = palmitic acid at 29; C16 = palmitic acid
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 subtype B
23
IC50
PMID29899103 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29899103/
RECORD: Rec_0365980 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 29 is Cys-Chol(cholesterol)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3(X4):inhibition of virus replication in TZM-bl cells
0±0 μM
IC50
PaperPubMed PMID: 30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
RECORD: Rec_0370829 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16 = palmitic acid at 29; C16 = palmitic acid
Bio-Activity Profile
Antiviral
HIV-1 LAI subtype B
17
IC50
PMID29899103 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29899103/
RECORD: Rec_0372285 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 29 is Cys-Chol(cholesterol)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (1A,2B,1C,1G,1A/C,1A/E,1B/C subtype) | HEK293T cells; TZM-bl cells
0.00001227 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDesign and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity. | Zhu Y, Chong H, Yu D, Guo Y, Zhou Y, He Y. | J Virol. 2019 May 15;93(11):e02312-18. | DOI:10.1128/JVI.02312-18 | PMID:30867304 PMID30867304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30867304/
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