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MYP_085656
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Basic Information
Nigroain-F
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C136H231N37O36S2
Standard
Sequence
GAFGNFLKGVAKKAGLKILSIAQCKLSGTC
Physicochemical Analysis
3024.65 Da
9.90
4.74
4.50
0.1578
0.51
0.62
0.21
-14.08
101.00
0.0667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1184.19
-11.88
43.0
43.0
106.0
211.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315068 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0316185 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Brevinin
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial Antifungal
Bacillus subtilis
12.5 μM
MIC
PaperTwo novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata
RECORD: Rec_0347580 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0400131 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans ATCC2002
6.25 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
RECORD: Rec_0412880 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Nigroain
127021
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
6.0 μM
MIC
PaperX. Liu et al. / Journal of Peptide Science 17 (2011) 68-72. Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata Evidence URLhttps://www.uniprot.org/uniprotkb/C0ILA6/entry
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