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MYP_085656
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Basic Information
Nigroain-F
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C136H231N37O36S2
Standard
Sequence
GAFGNFLKGVAKKAGLKILSIAQCKLSGTC
Physicochemical Analysis
3024.65 Da
9.90
4.74
4.50
0.1578
0.51
0.62
0.21
-14.08
101.00
0.0667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1184.19
-11.88
43.0
43.0
106.0
211.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0290438 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC43300
3.1 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
RECORD: Rec_0294022 VERIFIED: NO
Provenance & Taxonomy
Amphibia [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0298607 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Brevinin
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 2002
6.25 μM
MIC
PaperTwo novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata
RECORD: Rec_0304675 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa PA01
12.5 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
RECORD: Rec_0309771 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
rabbit red blood cell
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
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