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MYP_085656
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Basic Information
Nigroain-F
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C136H231N37O36S2
Standard
Sequence
GAFGNFLKGVAKKAGLKILSIAQCKLSGTC
Physicochemical Analysis
3024.65 Da
9.90
4.74
4.50
0.1578
0.51
0.62
0.21
-14.08
101.00
0.0667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1184.19
-11.88
43.0
43.0
106.0
211.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078042 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Nigroain
127021
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
0.7 μM
MIC
PaperX. Liu et al. / Journal of Peptide Science 17 (2011) 68-72. Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata Evidence URLhttps://www.uniprot.org/uniprotkb/C0ILA3/entry
RECORD: Rec_0098798 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ML-35P
25 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
RECORD: Rec_0106565 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Brevinin
127021
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300
3.1 μM
MIC
PaperTwo novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata
RECORD: Rec_0117530 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis
12.5 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
RECORD: Rec_0152638 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC27853
25 μg/mL
MIC
PMID21171145 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21171145/
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