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MYP_085591
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Basic Information
Laterosporulin 10
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
53 amino acids
C265H407N75O75S7
Standard
Sequence
ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL
Physicochemical Analysis
6067.98 Da
8.30
1.91
1.51
0.0361
-0.43
0.71
-0.04
27.34
62.45
0.1132
11460.00
11835.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2432.18
-22.16
88.0
86.0
198.0
422.0
11.0
58.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009722 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp. [Bacterium]
Bacteriocin
Structure & Mods
cyclic peptide [Cyclic]
all-D amino-acid peptide [D]
None
None
2-43, 6-35, 20-51
Disulphide bond between residues 2-43, 6-35 and 20-51
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium smegmatis MC2 155
45 μM
MIC
PMID27267959 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27267959/
RECORD: Rec_0028812 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp. SKDU10 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa MTCC 1934
PMID27267959 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27267959/
RECORD: Rec_0067172 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID28422156 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28422156/
RECORD: Rec_0112923 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp [Bacterium]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
microbial pathhogens such as M. tuberculosis strain H37Rv
0.5 μM
LD50
PaperLaterosporulin10: a novel defensin like Class IId bacteriocin from Brevibacillus sp. strain SKDU10 with inhibitory activity against microbial pathogens
RECORD: Rec_0124338 VERIFIED: YES
Provenance & Taxonomy
Brevibacillus sp. SKDU10 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus MTCC 1430
4 μM
MIC50
PMID27267959 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27267959/
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