Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length525 amino acids

Chemical FormulaC2550H4060N728O725S13

DescriptionStandard

        MSSLTANGAINPAARPCIRNGHRSEPSAQGGRLPGMGQSRPMEPPESPCTRRQDAHRGPRGEEPAVLPGAAHRGPRGEEPAALPGTARQYGVAVLEKKLSQLRLPDISGDFRVRHVGKVHYKISSLNLRSFHLPNSQISPIPNVGLQVSISSAFAKVDGNWRVKVHFIRDHGSFDLKVENLSIRISLKLGSDASGKPTADTSDCSTHISDVRIHFSGKLGWLYNLFHSAIESRFRRILESKVCENVVSSVHSELQPYLQTLPVTAKIDAVAGIDYSLVAPPAATAQSLDAGLKFFSVVHRSAVPFPPPPLAFPPDHARMVYFGASSYFFNTAGLTYHAAGALVLELTDSMIPKGLGFHLNTSAFSAFVPQLEKMYPDMLMKLRLSTPSAPFLSIDPAGLSLRPVVDIQAYAILPSSSLAPLFLLNLTANVSASIDVKSSRIVGNLTVGRLRLSLKHSDVGPFQVRTLQSIMNILASSILLPRLNARLGQGFPLPLPDRIQLSNVIVQSHQNFLLLGADVHYERRG
    

Molecular Weight56932.80 Da

Isoelectric Point (pI)9.81

Net Charge (pH 7.0)17.16

Net Charge (pH 7.4) 15.84

Charge Density (pH 7.0) 0.0327

GRAVY Index-0.05

Hydrophobic Moment 0.76

Boman Index0.07

Instability Index49.45

Aliphatic Index 95.31

Aromaticity 0.0686

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006642 VERIFIED: NO

Provenance & Taxonomy

OrganismApteryx mantelli mantelli [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria