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MYP_085579
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Basic Information
NTW (S-S)[T6A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Standard
13 amino acids
C64H85N17O15S2
Standard
Sequence
ACFPWGNAWCGGK
Physicochemical Analysis
1396.59 Da
8.10
0.78
0.56
0.0596
-0.05
0.15
0.30
44.08
15.38
0.2308
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
504.42
-3.79
19.0
18.0
38.0
98.0
6.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001791 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-10
Disulfide bond between Cys2 and Cys10
Bio-Activity Profile
Antiviral Anti-HCV
Hepatitis C virus(HCV)
11 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase. | Amin A, Zaccardi J, Mullen S, Olland S, Orlowski M, Feld B, Labonte P, Mak P. | Virology. 2003 Aug 15;313(1):158-69. | DOI:10.1016/s0042-6822(03)00313-1 | PMID:12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0208425 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-10
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/
RECORD: Rec_0237558 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-10
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus(HCV):inhibition of polymerase activity
11 μM
IC50
PaperPubMed PMID: 12951030 PMID12951030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12951030/