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MYP_085573
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Basic Information
C8- N27
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
27 amino acids
C136H235N45O40
Standard
Sequence
RQLLSGIVQQQNNLLRAIEAQQHLLQK
Physicochemical Analysis
3140.60 Da
10.84
1.85
1.59
0.0685
-0.47
0.57
-0.13
67.36
133.70
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1443.76
-15.21
47.0
43.0
113.0
221.0
1.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283494 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C16(hexadecanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0290613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C8(octanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0309508 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C8(octanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of peptide against virus-cell fusion on CD4-expressing cells
0.293±0.027 μM
IC50
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0329892 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C12(dodecanoic acid)
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
RECORD: Rec_0365936 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
TZM-bl
0.338 μM
IC50
PaperVirus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain. PMID20605950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20605950/
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