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MYP_085487
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Basic Information
Hepcidin TI2-3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C89H145N33O27S6
Standard
Sequence
QSHLSLCRWCCNCCRSNKGC
Physicochemical Analysis
2301.70 Da
8.70
2.79
2.44
0.1393
-0.39
0.66
-0.24
88.23
39.00
0.0500
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1000.47
-14.75
42.0
37.0
75.0
155.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033236 VERIFIED: NO
Provenance & Taxonomy
Oreochromis mossambicus [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer
RECORD: Rec_0043211 VERIFIED: YES
Provenance & Taxonomy
Neolamprologus brichardi [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0092844 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0100210 VERIFIED: YES
Provenance & Taxonomy
Oreochromis mossambicus [Animal]
8127
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization(Cys7 and Cys20)
7-20, 10-13, 11-14
Disulfide bonds between Cys7 and Cys20, Cys10 and Cys13, Cys11 and Cys14.; Cyclization(Cys7 and Cys20)
Bio-Activity Profile
Antiviral Anti-MDV Replication inhibition
Foot-and-Mouth Disease virus(FMDV) | BHK-21 cells
25.1±1.5 μg/mL
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperGrouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. | Huang HN, Pan CY, Chen JY. | Peptides. 2018 Aug;106:91-95. | DOI:10.1016/j.peptides.2018.07.003 | PMID:30012343 PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
RECORD: Rec_0129123 VERIFIED: YES
Provenance & Taxonomy
Oreochromis mossambicus [Animal]
Hepcidin
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
7-20, 10-13, 11-14
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 30012343 PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
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