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MYP_085483
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Basic Information
chassatide C4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C122H183N35O41S6
Standard
Sequence
GASCGETCFTGICFTAGCSCNPWPTCTRN
Physicochemical Analysis
2988.36 Da
5.96
-0.30
-0.59
-0.0102
0.10
0.38
0.15
34.27
20.34
0.1034
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1203.32
-18.85
48.0
47.0
87.0
204.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0313466 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic Anti-Gram-negative
Escherichia coli
80 μM
MIC
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0314648 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Animal]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-18; 8-20; 13-26
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus aureus
80 μM
MIC
PaperPubMed PMID: 22467870 PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0324016 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0339809 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0353002 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Chassalia chartacea
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
PMID22467870;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
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