Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length531 amino acids

Chemical FormulaC2678H4270N708O752S21

DescriptionStandard

        MGNRSCPPPPAPTGAFLLPLSTTALPFHRRLLRTSPVPLRGLEVWAALEDMAWGPDNVRKWSTLALLAIMGTALTAAINPGFVATISQKGLDFACQEGVVVLQKELEAIRIPDLTGVFKMKPLGKGYYDFYNMVVEGFHIPNPQIRLLPSEGLRLSIKDANIKISGRWTSKKNFLKARGKFGLSIQGVSFSTDLKLGKSSSGHITVNCSACESHIDSIHLQVSGSMLGWLIQLFHKKIEASLRNTIYEKICKIVTNSVSSKLQPYIQTLPLIARVDEVTRIDYSLMALTTTAEFLEGQLKGEFFWRGSRSSLPITPPAMSFSPNNDHMVHLSISDYFFNSAGLAYQESGTLKITLRDQMLPKDSKFRLNTEFLGTFLPKVAMKFPSTEVQLLITASEPPRLTIQPSGLSLDPALETQAFVVLQNSSLVPLFQLHMNTNASMEVDAEGDRLVGEVKLEKLMLELKRSDFGSFKVELLQAVINYLMPTLVVPKINERLRRGFPLPLPAEVKLNNIMFQSYQNFLVLRADVHRT
    

Molecular Weight59090.21 Da

Isoelectric Point (pI)9.29

Net Charge (pH 7.0)11.38

Net Charge (pH 7.4) 10.46

Charge Density (pH 7.0) 0.0214

GRAVY Index0.01

Hydrophobic Moment 0.73

Boman Index0.09

Instability Index43.39

Aliphatic Index 99.15

Aromaticity 0.0829

Extinction Coeff. Reduced 47900.00

Extinction Coeff. Oxidized 48150.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0075547 VERIFIED: NO

Provenance & Taxonomy

OrganismPeromyscus maniculatus bairdii [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria