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MYP_085361
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Basic Information
LIP5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Enzyme modulation ▸ Enzyme inhibition ▸ Complement inhibitor
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
not Standard
4 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XGXX
Physicochemical Analysis
0.00 Da
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0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025307 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C14, C-terminal= NH2, O: ornithine at 1; ornithine at 3,4; C14, C-terminal= NH2, O: ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC 29212
12.5 μg/mL
MIC
PMID34817038 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34817038/
RECORD: Rec_0161365 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C14, C-terminal= NH2, O: ornithine at 1; ornithine at 3,4; C14, C-terminal= NH2, O: ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
50 μg/mL
MIC
PMID34817038 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34817038/
RECORD: Rec_0173703 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Complement inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
1-(5-(2-methylpyrimidin-5-yl)-1H-indazol-3-yl)ethan-1-one
6-bromopyridin-2-amine
Non-standard residues/X at 1, 3, 4
Bio-Activity Profile
Complement inhibitor Immunomodulatory
Complement factor D
Clinical/Human: 7.9 h
Evidence URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624268/
RECORD: Rec_0180816 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C14, C-terminal= NH2, O: ornithine at 1; ornithine at 3,4; C14, C-terminal= NH2, O: ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
100 μg/mL
MIC
PMID34817038 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34817038/
RECORD: Rec_0186856 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
C12, C-terminal= NH2, O: ornithine at 1; ornithine at 3,4; C12, C-terminal= NH2, O: ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
100 μg/mL
MIC
PMID34817038 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34817038/
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