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MYP_085305
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Basic Information
HPRP-A1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C101H156N24O18
Standard
Sequence
FKKLKKLFSKLWNWK
Physicochemical Analysis
1994.47 Da
10.70
5.75
5.54
0.3836
-0.83
0.77
-0.19
-6.23
78.00
0.2667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
721.74
-0.10
26.0
24.0
70.0
143.0
6.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099324 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
APD analysis reveals that this sequence is similar (60%) to HP (2-20) Q17W,D19W K: 40%, L: 20%, F=W: 13%. Chemical modification: N-terminal acetylation (XXE) and C-terminal amidation (XXA)
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
1 μM
MIC
PaperFunctional synergy of alpha-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo.
RECORD: Rec_0101516 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID31686873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31686873/
RECORD: Rec_0105278 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
B16
6.1±0.02 μM
IC50
PaperPubMed PMID: 30592418 PMID30592418 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30592418/
RECORD: Rec_0108110 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
APD analysis reveals that this sequence is similar (60%) to HP (2-20) Q17W,D19W K: 40%, L: 20%, F=W: 13%. Chemical modification: N-terminal acetylation (XXE) and C-terminal amidation (XXA)
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae ATCC 700603
4 μM
MIC
PaperFunctional synergy of alpha-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo.
RECORD: Rec_0126369 VERIFIED: YES
Provenance & Taxonomy
AMP [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26422386 PMID26422386 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26422386/
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