Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2595H4039N645O739S18

DescriptionStandard

        MCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIEYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERSDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVLATEPPVISLLPGNFTLDIPASIMILTQPKNLTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP
    

Molecular Weight56673.88 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-5.62

Net Charge (pH 7.4) -6.55

Charge Density (pH 7.0) -0.0111

GRAVY Index0.12

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index37.28

Aliphatic Index 101.93

Aromaticity 0.1063

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0110678 VERIFIED: NO

Provenance & Taxonomy

OrganismBos mutus grunniens (Wild yak) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

RECORD: Rec_0234607 VERIFIED: NO

Provenance & Taxonomy

OrganismBos mutus [Animal]

FamilyBPI/LBP

Tax ID30521