Peptide Database

Peptide NameSLAY-screened peptide P1338

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC109H171N35O27

DescriptionStandard

        PHVRDKPSRARIFTSTWHVI
    

Molecular Weight2403.74 Da

Isoelectric Point (pI)11.71

Net Charge (pH 7.0)3.13

Net Charge (pH 7.4) 2.97

Charge Density (pH 7.0) 0.1567

GRAVY Index-0.62

Hydrophobic Moment 0.56

Boman Index-0.17

Instability Index25.07

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 996.53

LogP -9.00

H-bond Donors 38.0

H-bond Acceptors 32.0

Rotatable Bonds 74.0

Heavy Atoms 171.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0061096 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/