Peptide Database

Peptide NameSLAY-screened peptide P5807

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H148N26O32S2

DescriptionStandard

        AYHRPCNESTYYSFPVSYVC
    

Molecular Weight2386.62 Da

Isoelectric Point (pI)6.77

Net Charge (pH 7.0)-0.14

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0069

GRAVY Index-0.41

Hydrophobic Moment 0.33

Boman Index0.04

Instability Index56.59

Aliphatic Index 34.00

Aromaticity 0.2500

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6085.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 931.45

LogP -8.82

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 66.0

Heavy Atoms 168.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0258832 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/