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MYP_085049
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Basic Information
SLAY-screened peptide P3734
Antimicrobial
Antimicrobial ▸ Antibacterial
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
3 amino acids
C14H26N6O4
Standard
Sequence
RAP
Physicochemical Analysis
342.39 Da
9.75
0.76
0.56
0.2534
-1.43
0.94
-0.60
70.87
33.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
174.63
-1.84
6.0
5.0
8.0
24.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0223059 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial
recombinant Escherichia coli surface-display screening
SLAY screening
PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/
RECORD: Rec_0251042 VERIFIED: YES
Provenance & Taxonomy
Bos raurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
16 μM
IC50