Peptide Database

Peptide NamePen a 1 tropomyosin-derived epitope

Function Ontology

Immunology ▸ Adverse immune reactivity ▸ Allergenicity ▸ Allergen-specific CD4 T-cell epitope

Immunology ▸ Epitope/vaccine antigen ▸ T-cell epitope ▸ Allergen-specific CD4 T-cell epitope

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC77H131N23O23S

DescriptionStandard

        RKYDEVARKLAMVEA
    

Molecular Weight1779.07 Da

Isoelectric Point (pI)8.50

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0509

GRAVY Index-0.61

Hydrophobic Moment 0.78

Boman Index-0.30

Instability Index19.46

Aliphatic Index 84.67

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 778.69

LogP -5.71

H-bond Donors 28.0

H-bond Acceptors 25.0

Rotatable Bonds 62.0

Heavy Atoms 124.0

Ring Count 1.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032791 VERIFIED: YES

Provenance & Taxonomy

OrganismPenaeus aztecus [Animal]

FamilyTropomyosin

Tax ID6690.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory Allergen-specific CD4 T-cell epitope

TargetHuman CD4 T cells (shrimp-allergic subjects)

MethodMHC-peptide binding assay; CFSE dilution; tritiated-thymidine incorporation; cytokine release assay

PaperEugene V Ravkov et al. Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes. Hum Immunol. 2013. PMID: 23993987. https://pubmed.ncbi.nlm.nih.gov/23993987/ ; https://pmc.ncbi.nlm.nih.gov/articles/PMC3870591/ PMID23993987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23993987/

RECORD: Rec_0227606 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory